Trentini Lab

Protein quality control and stress response

We want to understand the mechanisms of proteome homeostasis (proteostasis), i.e., how cells achieve the synthesis of correctly folded functional proteins, and how they avoid the build-up of potentially toxic protein aggregates. To that end, we use a combination of biochemical, fluorescence-based, and advanced mass spectrometry methods to characterize proteostasis pathways in human cell culture models.

Selected Publications

  • Eisenack TJ, and Trentini DB (2023). Ending a bad start: Triggers and mechanisms of co-translational protein degradation. Front Mol Biosci., 4:9:1089825.
  • Trentini DB, Pecoraro M, Tiwary S, Cox J, Mann M, Hipp MS, and Hartl FU (2020) Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation. Proc Natl Acad Sci U S A., 117(8): 4099-4108.